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KMID : 0895820080180040025
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Journal of Oriental Rehabilitation Medicine
2008 Volume.18 No. 4 p.25 ~ p.37
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The Effects of Ohyaksungi-san(Wuyaoshunqi-san) and Electrical Acupuncture on Nerve Regeneration after Crush Injury in Rat Sciatic Nerve
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Yang Mi-Sung
Shin Mi-Suk
An Hye-Lim
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Abstract
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Objectives :Ohyaksungi-san(Wuyaoshunqi-san) has been used for many years as a treatment for sciatica in oriental medicine. And electrical acupuncture also has been used as a treatment for sciatica in recent study. By the way, it is hard to find the study that apply two treatments in the same time. This study was designed to evaluate the effects of Ohyaksungi-san(Wuyaoshunqi-san) and electrical acupuncture on nerve regeneration after crush injury in rat sciatic nerve in the same time.
Methods : This study was designed with 4 subgroups to evaluate the effects of Ohyaksungi-san(Wuyaoshunqi-san) and electrical acupuncture on nerve regeneration. As control groups, group Ⅰ has not been treated during 3 weeks after crush injury in rat sciatic nerve. Group Ⅱ has been treated Ohyaksungi-san(Wuyaoshunqi-san), Group Ⅲ has been treated electrical acupuncture, and Group Ⅳ has been treated both during 3 weeks. This study has been estimated sciatic function index and change of GAP-43 immunoreactivity about sciatic nerve regeneration.
Results :1. The test for nerve regeneration had significantly good result of sciatic function index in the experimental groups as compared with control groups(p<.05). Especially, Group Ⅳ has the greatest result of sciatic function index. 2. GAP-43, the marker of nerve regeneration, more increased in the experimental groups as compared with control groups. Especially, Group Ⅳ has the greatest result of GAP-43.
Conclusion :Ohyaksungi-san(Wuyaoshunqi-san) and electrical acupuncture have good effects on nerve regeneration after crush injury in rat sciatic nerve.
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KEYWORD
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Ohyaksungi-san(Wuyaoshunqi-san), Electrical acupuncture, Sciatic nerve injury, GAP-43, Sciatic function index
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